Spatial mechanisms of gene regulation in metazoan embryos

Spatial mechanisms of gene regulation in metazoan embryos.

The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development. There appear to be three major types of embryogenesis: Type 1, a general form characteristic of most invertebrate taxa of today, in which lineage plays an important role in the spatial organizat...

Mechanisms of gene activation by metazoan enhancers

TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation.

In addition to TATA-binding protein (TBP), a key factor for transcription initiation, the metazoan-specific TBP-like factor TLF/TRF2 and the vertebrate-specific factor TBP2/TRF3 are known to be required for transcription of specific subsets of genes. We have combined an antisense-knockdown approach with transcriptome profiling to determine the significance and biological role of TBP-independent...

Regulation mechanisms in spatial stochastic development models

The aim of this paper is to analyze different regulation mechanisms in spatial continuous stochastic development models. We describe the density behavior for models with global mortality and local establishment rates. We prove that the local self-regulation via a competition mechanism (density dependent mortality) may suppress a unbounded growth of the averaged density if the competition kernel...

Epigenetic Mechanisms of Gene Regulation In

Ashley Garrett Rivenbark: Epigenetic Mechanisms of Gene Regulation in Human Breast Cancer (Under the direction of William B. Coleman, Ph.D.) Breast cancer represents a significant health problem and improvements in our ability to prevent, diagnose, and treat the disease requires a greater understanding of the molecular basis of breast carcinogenesis. Epigenetic mechanisms play a major role in b...